Emerging research suggests that gut health plays an important role in skin health. Individuals with eczema often exhibit differences in their gut microbiota and immune responses compared with those without eczema, leading scientists to investigate whether specific probiotic strains may help support healthy skin and immune balance.

LBB™2 contains two extensively studied probiotic strains: BB-12® (Bifidobacterium animalis subsp. lactis) and LGG® (Lacticaseibacillus rhamnosus GG). These strains have been shown to interact with the immune system, helping to promote a balanced immune response and support the integrity of the gut barrier. Since immune activity in the gut can influence inflammation throughout the body, including the skin, maintaining a healthy gut microbiome may contribute to overall skin wellness.

In clinical studies involving infants with atopic eczema, supplementation with BB-12® or LGG® was associated with improvements in eczema severity and changes in immune markers linked to allergic inflammation. Researchers proposed that these probiotic strains may help regulate immune responses that contribute to eczema symptoms.

The combination of LGG® and BB-12® has also been identified in systematic reviews as one of the more promising probiotic combinations studied for reducing the risk of atopic dermatitis in children, highlighting the potential role of these strains in supporting healthy immune development and skin health.

While probiotics are not a replacement for medical treatment, the clinically documented strains in LBB™2 may help support the gut-skin axis, promote immune balance, and contribute to overall skin wellness as part of a comprehensive approach to managing eczema-prone skin.

LBB™2 contains two of the world's most extensively researched probiotic strains: BB-12® (Bifidobacterium animalis subsp. lactis) and LGG® (Lacticaseibacillus rhamnosus GG).

These probiotic strains are specifically selected for their ability to survive passage through the digestive tract, reach the intestine alive, and support a healthy balance of beneficial gut bacteria. Clinical studies have demonstrated that BB-12® and LGG® can help maintain gastrointestinal health by supporting normal bowel function, gut microbial balance, and intestinal barrier function.

One of the largest probiotic clinical trials conducted on BB-12® involved more than 1,200 adults with low bowel movement frequency and abdominal discomfort. Participants receiving BB-12® experienced significantly improved bowel movement frequency compared with placebo, demonstrating a measurable benefit on digestive function and bowel regularity.

Additional studies have shown that BB-12® can increase the number of days with normal bowel movements, improve stool consistency, and support healthy intestinal transit time. These effects are important indicators of a well-functioning digestive system.

Beyond digestive comfort, BB-12® has also been shown to increase secretory IgA (sIgA) levels in the gut. Secretory IgA is a key component of the intestinal immune barrier and helps protect the gastrointestinal tract from harmful microorganisms while supporting a healthy gut environment.

Together, the clinically documented strains BB-12® and LGG® help support digestive wellness by promoting healthy gut flora, maintaining normal bowel function, supporting the intestinal barrier, and contributing to overall gastrointestinal health.